Characterization of Eukaryotic Core Promoters Based on Nonlinear Dimensionality Reduction
نویسنده
چکیده
Characterization and identification of eukaryotic promoter is important for the gene prediction and genome annotation. In this paper, we study the structural characteristics of the core promoters in several eukaryotes through a series of DNA physicochemical properties and adopt a method that combines the alignment and average of multiple promoters and the nonlinear dimensionality reduction technique. The result shows that the eukaryotic core promoters have very special structural characteristics that are coherent between different species and independent of their sequence compositions.
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